NEONATAL DISEASE

Necrotising Enterocolitis

Necrotising enterocolitis (NEC), an inflammatory bowel disease of infants marked by necrosis is the most common gastrointestinal emergency in preterm neonates and a major cause of morbidity and mortality in neonatal intensive care units throughout the world.

The incidence of NEC is estimated to be 1–3 per 1000 live births, with more than 90% of all cases occurring in preterm infants. Research has shown NEC was recorded in 11.5%, 9%, 6%, and 4% of infants weighing 401–750g, 751–1000g, 1001–1250g, and 1251–1500g, respectively. Despite improvements in neonatal intensive care and increased overall survival of critically ill premature neonates, mortality rates from NEC can still reach 50%.

Cross section of healthy small intestine
.
Cross section of NEC small intestine
(Inflamed wall with gas bubbles)
Cross section of healthy small intestine
.
Cross section of NEC small intestine
(Inflamed wall with gas bubbles)

Secondary Indication – Pulmonary Hypoplasia

Pulmonary Hypoplasia
Genetic factors
Maternal factors
Infection
Medical Ventilation
Pulmonary Vascular Disease
abnormal function
vasoreactivity
vascular tone
hemodynamic instability
Disrupted Vascular Growth
hypoxemia
vascular remodeling
pulmonary vascular resistance
Pulmonary Vascular Disease
Abnormal function
Vasoreactivity
Vascular tone
Hemodynamic instability
Pulmonary Hypoplasia
Genetic factors
Maternal factors
Infection
Medical Ventilation
Disrupted Vascular Growth
Hypoxemia
Vascular remodeling
Pulmonary vascular resistance

Babies born prematurely can have underdeveloped lungs. This condition is named Pulmonary Hypoplasia. Pulmonary hypoplasia (PH) or aplasia is a rare condition that is characterized by incomplete development of lung tissue, which can be unilateral or bilateral. It results in a reduction in the number of lung cells, airways, and alveoli that results in impaired gas exchange. The true incidence of pulmonary hypoplasia is unknown. The reported incidence is between 9 to 11 per 100,00 live birth which is an underestimation, as infants with lesser degrees of hypoplasia likely survive in the neonatal period.

In different studies, mortality rates associated with PH are reported to be as high as 71-95% in the perinatal period.

The principle modes of action of MRG1061 in both indications are through:

  • Decreased inflammation
  • Activation of resident stem cell and tissue specific progenitor cell populations
  • Increased angiogenesis
  • Anti-apoptotic and chemotactic signalling
  • Beneficial remodelling of the extracellular matrix

The principle modes of action of MRG1061 in both indications are through:

  • Decreased inflammation
  • Activation of resident stem cell and tissue specific progenitor cell populations
  • Increased angiogenesis
  • Anti-apoptotic and chemotactic signalling
  • Beneficial remodelling of the extracellular matrix

WHAT WE DO

  1. THE SCIENCE
  2. THE TECHNOLOGY
  3. NEONATAL DISEASE
  4. AGE-ASSOCIATED CONDITIONS